The report provides a brief overview about the practical cyber-attacks that were performed in the 2022 ICNAP Study “Cybersecurity Lab” and a theoretical guideline on how to enable security in an operation technology (OT) environment of manufacturing companies. The complete guidebook is accessible online in the ICNAP Digital Services and can also be downloaded as PDF.The theoretical guideline on how to enable security in an operational technology (OT) environment of manufacturing is structured in a three-step process. First, the general Defense-in-Depth strategy is introduced to provide a basic understanding on a layered security approach at different levels of the organization. Second, the four application areas Process, Organization, People, and Technology are introduced to provide a structure on the different application areas that security measures affect. Lastly, the NIST security framework and its five phases are introduced. In each phase a brief description of the most relevant tasks is introduced.